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Published on: October 12, 2012

Effect of low molecular weight heparin (enoxaparin) on congenital cataract surgery

Ihsan Caça1, Alparslan Sahin, Abdullah Kürsat Cingü

  • 1Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.

International Journal of Ophthalmology
|November 21, 2012
PubMed

Insights

Intracameral enoxaparin significantly reduced postoperative inflammation in congenital cataract surgery. The anti-inflammatory effect of enoxaparin was dose-dependent, with lower complication rates observed in treated groups.

Area of Science:

  • Ophthalmology
  • Pediatric Surgery
  • Pharmacology

Background:

  • Congenital cataracts require surgical intervention, often leading to postoperative inflammation.
  • Managing intraocular inflammation is crucial for favorable surgical outcomes in pediatric cataract patients.

Purpose of the Study:

  • To evaluate the efficacy of varying doses of intracameral enoxaparin in mitigating postoperative inflammatory responses following congenital cataract surgery.
  • To determine if the anti-inflammatory effect of enoxaparin is dose-dependent in this context.

Main Methods:

  • A prospective, randomized controlled trial involving 80 eyes of 53 children with congenital cataracts.
  • Eyes underwent primary posterior capsulorrhexis and intraocular lens (IOL) implantation.
  • Participants were divided into four groups: one receiving balanced salt solution (BSS) alone, and three receiving BSS with 40mg, 20mg, or 10mg of enoxaparin.

Main Results:

  • Intracameral enoxaparin significantly reduced the number of inflammatory cells in the anterior chamber compared to the control group (P<0.001).
  • Lower rates of fibrin formation and IOL precipitates were observed in enoxaparin-treated groups, particularly at higher doses.
  • No significant differences in synechiae formation or IOL subluxation were noted across the groups.

Conclusions:

  • Intracameral enoxaparin effectively decreases postoperative inflammatory complications in congenital cataract surgery.
  • The anti-inflammatory benefits of enoxaparin were found to be dose-dependent.
  • Enoxaparin represents a promising adjunct for managing inflammation in pediatric cataract surgery.
Abstract

Keywords:
congenital cataractenoxaparininflammatory response

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