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Related Experiment Video

Updated: May 16, 2026

Simultaneous Evaluation of Cerebral Hemodynamics and Light Scattering Properties of the In Vivo Rat Brain Using Multispectral Diffuse Reflectance Imaging

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Multi-modality imaging on multiple evanescent white dot syndrome-A Spectralis Study.

Rui Hua¹, Kang Chen, Li-Min Liu

¹Department of Ophthalmology, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province China.

International Journal of Ophthalmology

|November 21, 2012

Summary

Multiple evanescent white dot syndrome (MEWDS) is a self-healing condition affecting retinal microstructure. Advanced imaging like Spectralis OCT and two-wavelength autofluorescence aids in analyzing its metabolic and functional changes.

Keywords:

BL-FAF MEWDS NIR-FAF Spectralis OCT mf-ERG

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Area of Science:

Ophthalmology
Retinal Imaging
Neuro-ophthalmology

Background:

Multiple evanescent white dot syndrome (MEWDS) is an idiopathic inflammatory condition affecting the outer retina.
While typically self-resolving, understanding its microstructural and metabolic changes is crucial for diagnosis and management.

Purpose of the Study:

To characterize the retinal microstructure, metabolism, and function in MEWDS using multimodal imaging.
To observe the disease's progression and resolution using enhanced depth imaging spectral-domain optical coherence tomography (EDI-SD-OCT) and two-wavelength autofluorescence.

Main Methods:

A case study of a 23-year-old female with MEWDS.
Multimodal imaging included blue light-fundus autofluorescence (BL-FAF), near-infrared fundus autofluorescence (NIR-FAF), fluorescein angiography (FFA), indocyanine green angiography (ICGA), EDI-SD-OCT, and multifocal electroretinography (mf-ERG).
Follow-up examination was conducted at eight months.

Main Results:

OCT revealed transient disruption of foveal photoreceptor outer segments and granularity.
NIR-FAF showed hypoautofluorescent areas, while BL-FAF showed hyperfluorescence that resolved over time.
Mf-ERG demonstrated reduced responses in the fovea and macula. Structural recovery was observed by eight months, with decreased subfoveal choroidal thickness.

Conclusions:

MEWDS is a benign, self-healing disease.
EDI-SD-OCT provides histopathology-like detail of microstructural changes.
Two-wavelength FAF and mf-ERG offer insights into outer retinal metabolism (RPE and photoreceptors).
Combined Spectralis OCT, two-wavelength FAF, and mf-ERG offer a comprehensive approach for analyzing MEWDS, aiding therapy and follow-up.