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A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit
Published on: November 21, 2023
[Research progress of protective effects of alendronate on articular cartilage in osteoarthritis]
Dingwen He1, Ming Yin, Yuanyi Luo
1No.1 Department of Orthopaedics, Second Affiliated Hospital of Nanchang University, Nanchang Jiangxi 330006, PR China.
Objective:
To summarize the recent development on chondroprotective effect of alendronate (ALN) on articular cartilage in osteoarthritis (OA).
Methods:
The related literature was reviewed and the main achievements in vitro/vivo studies in the fields were summarized.
Results:
ALN can improve the metabolic microenvironment of the articular cartilage in OA, inhibit subchondral bone remodeling, so it has potential protective effect on articular cartilage.
Conclusion:
ALN is expected to become a disease-modifying OA drug in future, but OA treatment still lack a uniform basic and clinical evaluation criteria, so it has guiding significance in development and application of ALN to develope a uniform standard and obtain the clinical data.
