Related Experiment Video
Updated: May 16, 2026
Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation
Published on: December 30, 2021
[Related issues in clinical translational application of adipose-derived stem cells]
Hongwei Liu1, Biao Cheng, Xiaobing Fu
1Department of Plastic Surgery, First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine, Ministry of Education, Guangzhou Guangdong 510630, PR China.
Objective:
To introduce the related issues in the clinical translational application of adipose-derived stem cells (ASCs).
Methods:
The latest papers were extensively reviewed, concerning the issues of ASCs production, management, transportation, use, and safety during clinical application.
Results:
ASCs, as a new member of adult stem cells family, bring to wide application prospect in the field of regenerative medicine. Over 40 clinical trials using ASCs conducted in 15 countries have been registered on the website (http://www.clinicaltrials.gov) of the National Institutes of Health (NIH), suggesting that ASCs represents a promising approach to future cell-based therapies. In the clinical translational application, the related issues included the quality control standard that management and production should follow, the prevention measures of pathogenic microorganism pollution, the requirements of enzymes and related reagent in separation process, possible effect of donor site, age, and sex in sampling, low temperature storage, product transportation, and safety.
Conclusion:
ASCs have the advantage of clinical translational application, much attention should be paid to these issues in clinical application to accelerate the clinical translation process.
