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[Research progress of bone morphogenetic protein and liability of ossification of posterior longitudinal ligament]
Zhao Fang1, Tianwei Sun, Sandip Kumar Yadav
1Department of Spinal Surgery, Nankai University Affiliated Hospital, Tianjin 300121, PR China.
Objective:
To review the research progress of bone morphogenetic protein (BMP) and the liability of ossification of the posterior longitudinal ligament (OPLL).
Methods:
Recent literature concerning BMP and the liability of OPLL was reviewed, analysed, and summarized.
Results:
The single nucleotide polymorphisms (SNPs) of BMP gene may produce a minor cumulative effect and increase individual susceptibility to OPLL. A variety of environmental factors can promote the occurrence and development of OPLL by increasing the expression of BMP gene.
Conclusion:
The SNPs of BMP gene may increase individual susceptibility to OPLL. However, interaction of cumulative effect of the SNPs and environmental factors can promote the liability to OPLL.
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