Association between TP53 Arg72Pro polymorphism and hepatocellular carcinoma risk: a meta-analysis

Area of Science:

• Genetics
• Oncology
• Molecular Epidemiology

Background:

• Previous research on the TP53 Arg72Pro polymorphism and hepatocellular carcinoma (HCC) risk yielded conflicting results.
• This study addresses the need for a comprehensive analysis to clarify the association.

Purpose of the Study:

• To conduct a meta-analysis to quantify the association between the TP53 Arg72Pro polymorphism and HCC risk.
• To investigate potential race-specific effects of this polymorphism on HCC susceptibility.

Main Methods:

• A systematic literature search was performed on PubMed and Wangfang databases.
• Meta-analysis was conducted using pooled odds ratios (OR) and 95% confidence intervals (95% CI).

Main Results:

• Ten studies comprising 2,026 HCC cases and 2,733 controls were included.
• The TP53 Arg72Pro polymorphism was associated with increased HCC risk in Caucasians across multiple genetic models.
• No significant association was found between the TP53 Arg72Pro polymorphism and HCC risk in East Asians.

Conclusions:

• The TP53 Arg72Pro polymorphism shows a significant association with HCC risk in Caucasian populations.
• Evidence suggests a potential race-specific effect of the TP53 Arg72Pro polymorphism on HCC risk, warranting further investigation.