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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

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Related Experiment Video

Updated: May 16, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Donor specific transplant tolerance is dependent on complement receptors.

Gregor Bartel1, Kathryn Brown, Richards Phillips

  • 1MRC Centre for Transplantation, King's College London, School of Medicine at Guy's, King's and St. Thomas' Hospitals, London, UK.

Transplant International : Official Journal of the European Society for Organ Transplantation
|November 22, 2012
PubMed
Summary

The complement system, specifically complement component 3a receptor (C3aR), is vital for inducing transplant tolerance. Its deficiency disrupts T regulatory cell function, hindering successful transplantation.

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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
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Published on: May 2, 2013

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Last Updated: May 16, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Area of Science:

  • Immunology
  • Transplantation Biology
  • Complement System Research

Background:

  • The complement system's role in transplant tolerance is increasingly recognized but not fully understood.
  • Donor lymphocyte infusion is a model for studying transplant tolerance induction.

Purpose of the Study:

  • To elucidate the mechanisms by which the complement system mediates transplant tolerance.
  • To investigate the specific roles of complement receptors, including C3aR, in this process.

Main Methods:

  • Utilized a rodent model of donor lymphocyte infusion-induced transplant tolerance.
  • Examined the impact of deficiencies in complement receptors (DAF, CR3, C3aR) on tolerance induction.
  • Conducted ex vivo studies to assess T regulatory and T effector cell populations and function.

Main Results:

  • Transplant tolerance induction was dependent on decay accelerating factor, complement receptor 3, and C3aR.
  • C3aR on both donor and recipient cells mediated complement-dependent tolerance.
  • C3aR deficiency resulted in an imbalance of T regulatory and T effector cells, with reduced regulatory function.

Conclusions:

  • Multiple complement receptors are crucial for effective transplant tolerance induction.
  • Complement facilitates the generation and function of T regulatory cells, essential for preventing graft rejection.
  • These findings offer new insights into the mechanisms of complement-mediated transplant tolerance.