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Published on: January 28, 2020
[Evaluation of circulating microRNA-92a for endothelial damage induced by percutaneous coronary intervention]
Objective:
To explore the role of microRNA-92a (miR-92a) in evaluating endothelium damage induced by percutaneous coronary intervention (PCI).
Methods:
A case control study was prospectively conducted. Fifty-eight patients with ST-segment elevation acute myocardial infarction (STEAMI) received PCI were enrolled. MiR-92a expression in circulation was determined on the next day after PCI (reverse transcription-polymerase chain reaction). The correlation between miR-92a expression in circulation and PCI influence factors, such as inflation pressure, duration of balloon inflation and length of culprit atheromatous plaque were explored.
Results:
MiR-92a was lower in inflation pressure 11-19 atm (1 atm=101.325 kPa) group [n=43, mean -0.36, 95% confidence interval (95%CI) -0.60 to -0.12] than inflation pressure ≤10 atm group (n=11, mean 1.16, 95%CI 0.80 to 1.52, P<0.01) and ≥ 20 atm group (n=4, mean 0.26, 95%CI 0.26 to 0.26, P=0.1); and also lower in duration of balloon inflation 6-7 seconds group (n=24, mean -0.42, 95%CI -0.83 to -0.01) than in duration of balloon inflation ≤ 5 seconds group (n=9, mean 0.63, 95%CI 0.49 to 0.78, P=0.03) and ≥ 8 seconds group (n=25, mean 0.45, 95%CI 0.10 to 0.80, P<0.001); lower in implanted stent length ≤30 mm (n=31, mean -0.48, 95%CI -0.80 to -0.16) than those >30 mm (n=27, mean 0.16, 95%CI 0.01 to 0.32, P<0.01). A significantly negative correlation was found between inflation pressure and duration of balloon inflation. (r=-0.48, P<0.001).
Conclusions:
There is a relationship between circulating miR-92a, inflation pressure and duration of balloon inflation. Circulating miR-92a could be used to evaluate the endothelium injury induced by PCI, and be used as a new target of prevention and treatment of endothelial dysfunction following revascularization.
Insights
Circulating microRNA-92a (miR-92a) levels correlate with percutaneous coronary intervention (PCI) parameters. Lower miR-92a indicates potential endothelium damage, suggesting its use in evaluating PCI-induced injury.
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- Biomarker Discovery
Context:
- Percutaneous coronary intervention (PCI) is a common procedure for treating coronary artery disease.
- Endothelial dysfunction is a significant complication following PCI.
- Identifying reliable biomarkers for assessing PCI-induced endothelial injury is crucial.
Purpose:
- To investigate the association between circulating microRNA-92a (miR-92a) levels and endothelial damage after PCI.
- To explore the correlation of miR-92a expression with procedural factors of PCI, including inflation pressure, balloon inflation duration, and stent length.
Summary:
- A case-control study involving 58 patients with ST-segment elevation acute myocardial infarction (STEMI) undergoing PCI was conducted.
- Circulating miR-92a levels were measured post-PCI and correlated with procedural parameters.
- Results indicated lower miR-92a levels with increased inflation pressure, longer balloon inflation duration, and longer stent length, alongside a negative correlation between inflation pressure and balloon duration.
Impact:
- Circulating miR-92a shows potential as a biomarker for evaluating PCI-induced endothelial injury.
- miR-92a may serve as a novel therapeutic target for preventing and treating post-PCI endothelial dysfunction.
- This research contributes to optimizing PCI procedures and improving patient outcomes.
