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You don't say: dynamic aphasia, another variant of primary progressive aphasia?
David L Perez1, Bradford C Dickerson, Scott M McGinnis
1Department of Neurology, Center for Brain/Mind Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Abstract:
Primary progressive aphasia (PPA) is a language predominant neurodegenerative disorder that has three recognized variants: nonfluent/agrammatic, semantic, and logopenic. This report describes a 60-year-old man who presented with a progressive decline in verbal output that does not fit the currently accepted PPA subtypes. The patient exhibited a paucity of verbal output and impaired phonemic fluency with minimal associated language, cognitive, or behavioral deficits. Focal cortical thinning/hypometabolism of the left superior frontal region and a cerebrospinal fluid profile not consistent with Alzheimer's disease pathology were identified. This case of isolated progressive dynamic aphasia extends the current boundaries of PPA diagnostic variants.
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