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Updated: May 16, 2026
Primer-Free Aptamer Selection Using A Random DNA Library
Published on: July 26, 2010
Rational design of Hg2+ controlled streptavidin-binding aptamer
Hongcheng Mei1, Tao Bing, Cui Qi
1Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Abstract:
Through substituting two canonical base pairs of a streptavidin-binding aptamer with T-T mismatched base pairs, a new aptamer was constructed. Its binding ability could be controlled by Hg(2+) through the formation of T-Hg-T metal-base pairs.
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