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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Tracheobronchopathia osteochondroplastica: an unusual presentation.

Ipek Ozmen1, Nilufer A Kongar, Korkmaz Oruc

  • 1*Chest Disease Department; †Pathology Department, Sureyyapasa Chest Diseases and Thoracic Surgery Teaching and Research Hospital, Istanbul, Turkey.

Journal of Bronchology & Interventional Pulmonology
|November 22, 2012
PubMed
Summary

Tracheobronchopathia osteochondroplastica is a rare condition causing bony growths in the airway. This case highlights its diagnosis through imaging and biopsy, aiding in understanding this unusual respiratory disease.

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10:01

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Published on: July 10, 2012

Area of Science:

  • Pulmonology
  • Rare Diseases
  • Histopathology

Background:

  • Tracheobronchopathia osteochondroplastica (TO) is a rare, benign condition.
  • It involves the formation of cartilaginous and osseous submucosal nodules.
  • These nodules protrude into the trachea and large bronchi, causing airway obstruction.

Purpose of the Study:

  • To present a case of tracheobronchopathia osteochondroplastica.
  • To illustrate the diagnostic process for this rare airway disease.
  • To contribute to the understanding of TO's clinical presentation and pathology.

Main Methods:

  • Patient presentation with chronic cough and noisy breathing.
  • Diagnostic imaging including chest X-ray and computed tomography (CT) of the thorax.
  • Flexible bronchoscopy with histopathological examination of nodules.

Main Results:

  • Chest X-ray showed diffuse tracheal lumen irregularity and narrowing.
  • Thorax CT revealed tracheal and bronchial irregularity, stenosis, and ossification.
  • Bronchoscopy identified multiple nodules protruding into the tracheal lumen.
  • Histopathology confirmed tracheobronchopathia osteochondroplastica.

Conclusions:

  • Tracheobronchopathia osteochondroplastica is characterized by submucosal cartilaginous and osseous nodules.
  • Diagnosis is confirmed via histopathology after imaging and bronchoscopy.
  • The etiology of TO remains unexplained, necessitating further research.