Peripheral T-cell lymphoma with endobronchial involvement

Peripheral T-cell lymphoma unspecified (PTCL-U) is a lymphoproliferative disorder characterized by localized malignant T-lymphocyte infiltration of the skin. PTCL-U is a rare disease of the elderly with a low 5-year survival rate (16%). The skin is affected variably with localized plaques, nodules, or tumors. The lungs are involved in less than 10% of the cases. Nodules, masses, or mass-like consolidations are the most common pulmonary manifestations of PTCL-U. Pulmonary involvement by PTCL-U is associated with a poor prognosis. We report a case of PTCL-U presenting as an endobronchial and a parenchymal lesion before the skin manifestations. To our knowledge, this is the first report in the literature of pulmonary involvement preceding the dermatological manifestation of PTCL-U.