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Updated: May 16, 2026
09:21
Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
Published on: September 13, 2019
Renal pleomorphic undifferentiated sarcoma: a rarity
Suresh Kumar1, Punit Bansal, Punit Tiwari
1The Institute of Post-Graduate Medical Education and Research (IPGMER), Kolkota, West Bengal, India. sureshsingla08@gmail.com
Summary
A rare kidney cancer, pleomorphic undifferentiated sarcoma (PUS), formerly malignant fibrous histiocytoma (MFH), was diagnosed in a 70-year-old male. Despite surgery, the patient experienced metastasis and succumbed to the disease within 18 months.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Pleomorphic undifferentiated sarcoma (PUS), previously known as malignant fibrous histiocytoma (MFH), is a rare soft tissue sarcoma.
- Kidney sarcomas are uncommon, often presenting with nonspecific symptoms like weight loss.
Observation:
- A 70-year-old male presented with eight months of progressive weight loss.
- Imaging revealed a large right kidney tumor.
- Histopathology confirmed pleomorphic undifferentiated sarcoma (PUS/MFH) post-nephrectomy.
Findings:
- The patient developed pulmonary metastasis one year after radical nephrectomy.
- The sarcoma demonstrated aggressive behavior with rapid progression.
Implications:
- This case highlights the challenges in diagnosing and managing rare kidney sarcomas.
- Early detection and aggressive treatment strategies are crucial for improving outcomes in PUS/MFH.
- Further research into the molecular mechanisms and targeted therapies for PUS/MFH is warranted.
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