Related Experiment Video

Updated: May 16, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Renal pleomorphic undifferentiated sarcoma: a rarity

Suresh Kumar1, Punit Bansal, Punit Tiwari

  • 1The Institute of Post-Graduate Medical Education and Research (IPGMER), Kolkota, West Bengal, India. sureshsingla08@gmail.com

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|November 22, 2012
PubMed

Insights

A rare kidney cancer, pleomorphic undifferentiated sarcoma (PUS), formerly malignant fibrous histiocytoma (MFH), was diagnosed in a 70-year-old male. Despite surgery, the patient experienced metastasis and succumbed to the disease within 18 months.

Area of Science:

  • Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Pleomorphic undifferentiated sarcoma (PUS), previously known as malignant fibrous histiocytoma (MFH), is a rare soft tissue sarcoma.
  • Kidney sarcomas are uncommon, often presenting with nonspecific symptoms like weight loss.

Observation:

  • A 70-year-old male presented with eight months of progressive weight loss.
  • Imaging revealed a large right kidney tumor.
  • Histopathology confirmed pleomorphic undifferentiated sarcoma (PUS/MFH) post-nephrectomy.

Findings:

  • The patient developed pulmonary metastasis one year after radical nephrectomy.
  • The sarcoma demonstrated aggressive behavior with rapid progression.

Implications:

  • This case highlights the challenges in diagnosing and managing rare kidney sarcomas.
  • Early detection and aggressive treatment strategies are crucial for improving outcomes in PUS/MFH.
  • Further research into the molecular mechanisms and targeted therapies for PUS/MFH is warranted.

More Related Videos

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...