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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
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Multislice cardiac arterial spin labeling using improved myocardial perfusion quantification with simultaneously

Adrienne E Campbell-Washburn1, Hui Zhang, Bernard M Siow

  • 1Centre for Advanced Biomedical Imaging, Division of Medicine and Institute of Child Health, University College London, UK; Department of Medical Physics and Bioengineering, University College London, UK.

Magnetic Resonance in Medicine
|November 22, 2012
PubMed
Summary

A new method for multislice cardiac arterial spin labeling accurately quantifies myocardial blood flow (MBF) using blood pool magnetization. This blood pool magnetization (bpMBF) quantification technique enables precise perfusion measurements for cardiac disease research.

Keywords:
arterial spin labelingcardiaclook‐lockermultisliceperfusionperfusion model

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Area of Science:

  • Cardiovascular Imaging
  • Magnetic Resonance Imaging (MRI)

Background:

  • Myocardial blood flow (MBF) is a critical metric for assessing cardiac health.
  • Arterial spin labeling (ASL) is a non-invasive MRI technique for MBF measurement.
  • Current ASL methods face challenges in accurate multislice myocardial perfusion quantification.

Purpose of the Study:

  • To develop and validate a novel blood pool magnetization (bpMBF) quantification method for multislice cardiac arterial spin labeling.
  • To enable accurate MBF measurements in cardiac tissues using a new ASL approach.

Main Methods:

  • A multislice segmented ECG-gated Look-Locker T1 mapping sequence was employed.
  • Blood pool magnetization was directly measured to approximate the arterial input function for Bloch equations.
  • Simulations and in vivo mouse heart studies were conducted to evaluate the bpMBF method.

Main Results:

  • Blood pool magnetization recovery to equilibrium took approximately 3 seconds post-inversion.
  • The bpMBF quantification method demonstrated robustness against variations in slice-selective thickness.
  • In vivo results showed good agreement between single and multislice perfusion values using bpMBF, unlike traditional methods.

Conclusions:

  • The study presents the first multislice cardiac arterial spin labeling technique.
  • The developed bpMBF quantification method allows for accurate myocardial perfusion measurements.
  • This technique is valuable for future studies investigating cardiac diseases.