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Gastrointestinal Motility Monitor (GIMM)

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Published on: December 1, 2010

The Global Enteric Multicenter Study (GEMS): impetus, rationale, and genesis.

Myron M Levine¹, Karen L Kotloff, James P Nataro

¹Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA. mlevine@medicine.umaryland.edu

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

|November 22, 2012

Summary

Diarrheal disease is a major cause of child deaths. The Global Enteric Multicenter Study (GEMS) identified key pathogens and disease burden to guide vaccine development and reduce child mortality.

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Area of Science:

Global Health
Infectious Diseases
Pediatric Medicine

Background:

Diarrheal disease is a leading cause of mortality in young children globally.
Previous studies on diarrheal disease etiology had limitations, hindering pathogen prioritization for vaccine development.
A consensus emerged on the need for a robust study to inform global health strategies.

Purpose of the Study:

To determine the etiology and population-based burden of pediatric diarrheal disease.
To overcome methodological limitations of prior etiological studies.
To guide global investment and implementation decisions for diarrheal disease control.

Main Methods:

The Global Enteric Multicenter Study (GEMS) was designed as a large-scale case-control study.
GEMS enrolled approximately 12,600 cases and 12,600 controls across multiple sites.
The study involved demographic surveillance of nearly 467,000 child-years in Africa and Asia.

Main Results:

GEMS aimed to provide comprehensive data on the causes and severity of diarrheal disease in children.
The study's findings are intended to inform public health policies and interventions.
Data will help prioritize strategies to reduce diarrheal disease morbidity and mortality.

Conclusions:

GEMS provides crucial etiological and burden data for pediatric diarrheal disease.
The study's findings will guide the development and implementation of effective interventions.
This research is vital for mitigating the impact of diarrheal diseases on child survival.