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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Predictors of long-term survival in acute coronary syndrome patients with left ventricular dysfunction after

Doo Hwan Lee1, Myung Ho Jeong, Jung Ae Rhee

  • 1The Heart Center of Chonnam National University Hospital, Gwangju, Korea. ; The Heart Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.

Korean Circulation Journal
|November 22, 2012
PubMed

Insights

The 5-year survival rate for acute coronary syndrome patients with left ventricular dysfunction after PCI is 40%. Key mortality predictors include low left ventricular ejection fraction (LVEF), elevated serum creatinine, advanced age, and female gender.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Clinical Outcomes Research

Background:

  • Acute coronary syndrome (ACS) patients with left ventricular dysfunction face significant long-term mortality risks.
  • Percutaneous coronary intervention (PCI) is a common revascularization strategy, but outcomes in this high-risk group require further investigation.
  • Understanding predictors of mortality is crucial for risk stratification and management.

Purpose of the Study:

  • To identify independent predictors of 5-year mortality in patients with ACS and left ventricular dysfunction following PCI.
  • To analyze the long-term clinical outcomes and survival rates in this specific patient cohort.

Main Methods:

  • A cohort of 329 ACS patients with left ventricular ejection fraction (LVEF) below 40% who underwent PCI between 2001 and 2006 were followed for 5 years.
  • Patients were stratified into two groups: those surviving beyond 5 years and those with shorter survival.
  • Statistical analysis was performed to identify independent predictors of mortality using logistic regression.

Main Results:

  • The 5-year cumulative survival rate was 40%.
  • Independent predictors of mortality included LVEF <30% (OR=1.793), serum creatinine >3.0 mg/dL (OR=2.455), age >65 years (OR=1.594), and female gender (OR=1.524).
  • Patients with shorter survival were older, more likely to be female, and had lower LVEF compared to survivors.

Conclusions:

  • The 5-year mortality rate is substantial (60%) in ACS patients with left ventricular dysfunction post-PCI.
  • Low LVEF, elevated serum creatinine, older age, and female sex are significant independent predictors of mortality.
  • These findings highlight the need for targeted management strategies for high-risk ACS patients with impaired left ventricular function.
Abstract

Keywords:
Acute coronary syndromeAngioplastyHeart failurePrognosis

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