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Updated: May 16, 2026

CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells
Published on: June 2, 2022
Stromal CEACAM1 expression regulates colorectal cancer metastasis
Azadeh Arabzadeh1, Nicole Beauchemin
1Goodman Cancer Research Centre; McGill University; Montreal, QC Canada.
Abstract:
Colorectal cancer metastasis to Ceacam1-/- livers is significantly impaired, compared with wild type livers, due to decreased endothelial cell survival, reduced tumor cell proliferation, diminished immune infiltration and altered chemokine expression. Ceacam1-/- myeloid-derived suppressor cells diminish metastatic burden, as confirmed by bone marrow transplantation and adoptive transfer experiments.
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