Related Experiment Video
Updated: May 16, 2026

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
Published on: September 1, 2015
CD4 responses against IDO
1Center for Cancer Immune Therapy (CCIT); Department of Hematology; Copenhagen University Hospital; Herlev, Denmark.
Abstract:
Natural indoleamine-2,3-dioxygenase (IDO)-reactive CD4(+) T cells have been shown to release interferonγ (IFNγ), tumor necrosis factor α (TNFα), as well as interleukin 17 (IL-17). In some individuals, these cells also demonstrated the ability to suppress IL-10 production. IDO-specific CD4(+) helper T cells among peripheral blood lymphocytes may participate in immunoregulatory networks by delaying the immune suppressive actions of IDO. However, IDO-specific CD4(+) T cells may also have a regulatory phenotype, de facto exerting immunosuppressive functions.
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