Related Experiment Video
Updated: May 16, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
[Thalidomide and its legacy, the rational inside the irrational]
Daniel O Fadel1, Héctor Alejandro Serra
1I Cátedra de Farmacología, Facultad de Medicina, UCA. dfadel@fmed.uba.ar
Abstract:
Thalidomide was synthesized by Chemie Grünenthal from Germany and launched at October 1957, as a sedative and antiemetic drug. In only four years after being widely and freely prescribed to pregnant women, unleashed an epidemic of teratogenicity that revolutionized health and public opinion. From that moment, world regulation on drugs and its development was radically changed, the clinical trial as a tool was completely revised, while pharmacovigilance as a discipline was established. In a second chance, its irrational use as psychotropic drug was changed to use as immunomodulator, context in which it is prescribed today. This paper aims to highlight some historical aspects of thalidomide to draw conclusions for rational use of psychotropic drugs.
More Related Videos
17:28Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
16:02Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
Related Concept Videos
Drug Regulation
Teratogenicity
Regression Toward the Mean
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
Intrauterine Drug Delivery Systems
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions