Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stereographic analysis of syringomas.

M Ito1, H Yokoyama, K Ikeda

  • 1Department of Dermatology, Niigata University School of Medicine, Japan.

Archives of Dermatological Research
|January 1, 1990
PubMed
Summary

Syringoma tumor nests form unique, interconnected structures in the skin, originating from a single focus. Computer analysis reveals their distinct growth patterns and constant ability to form lumina.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictors of the progression of diabetic nephropathy and the beneficial effect of angiotensin-converting enzyme inhibitors in NIDDM patients.

Diabetologia·1997
Same author

The current status of postoperative complications and risk factors after a pulmonary resection for primary lung cancer. A multivariate analysis.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·1997
Same author

Survival of Vi-capsulated and Vi-deleted Salmonella typhi strains in cultured macrophage expressing different levels of CD14 antigen.

FEMS microbiology letters·1997
Same author

[Recent progression in research on alcoholic liver disease].

Nihon rinsho. Japanese journal of clinical medicine·1997
Same author

[Pathogenesis of alcoholic liver disease].

Nihon rinsho. Japanese journal of clinical medicine·1997
Same author

[Biochemical marker of alcoholic liver disease].

Nihon rinsho. Japanese journal of clinical medicine·1997

Area of Science:

  • Dermatopathology
  • 3D Reconstruction
  • Tumor Biology

Background:

  • Syringomas are benign adnexal tumors originating from the intraepidermal duct of the eccrine sweat gland.
  • Understanding the three-dimensional (3-D) architecture of syringomas is crucial for elucidating their biological characteristics and pathogenesis.

Purpose of the Study:

  • To investigate the biological characteristics of syringomas.
  • To reconstruct and analyze the 3-D architecture of epithelial tumor nests and luminal structures in syringoma skin lesions.

Main Methods:

  • Computer stereographic analysis was employed to reconstruct 3-D architectures.
  • Analysis focused on epithelial tumor nests, luminal structures, hair follicles, and epidermal basement membrane.

Main Results:

  • Syringoma lesions comprised interconnected spherical to ovoid tumor nests resembling ginger roots or budding fungi.
  • Tumor nests developed around hair follicles and beneath the epidermis but were not connected to them.
  • A significant lumen volume to tumor nest volume ratio (0.275 +/- 0.037) indicated a constant ability to form luminal structures.

Conclusions:

  • Syringoma likely originates from a single focus in the upper dermis, independent of surrounding epithelial tissues.
  • Tumor growth involves swelling to form lumina, with peripheral parts becoming discrete.
  • Syringoma cells possess a consistent capacity for luminal structure formation.

Related Experiment Videos