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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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Related Experiment Video

Updated: May 16, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Clear cell acanthoma.

T Tempark1, T Shwayder

  • 1Department of Paediatrics, Chulalongkorn University, Bangkok, Thailand.

Clinical and Experimental Dermatology
|November 23, 2012
PubMed
Summary
This summary is machine-generated.

Clear cell acanthoma (CCA) is a benign skin lesion. Diagnosis can be challenging due to variable presentations, requiring biopsy for confirmation and guiding treatment.

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Last Updated: May 16, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Published on: August 18, 2022

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Clear cell acanthoma (CCA) is a benign skin neoplasm of unknown etiology.
  • It typically presents as a dome-shaped, red-to-brown papule, often on the leg.

Observation:

  • This case highlights an atypical presentation of CCA as hypopigmented papules in an irregular plaque.
  • The diagnosis was confirmed via biopsy, underscoring the importance of histopathology.

Findings:

  • CCA exhibits variable clinical presentations, including uncommon variants and locations.
  • Differential diagnosis is broad, encompassing other skin tumors and dermatoses.
  • Histopathology and immunohistochemistry are crucial for accurate diagnosis.

Implications:

  • Variable clinical appearance can complicate CCA diagnosis, necessitating biopsy.
  • Understanding variants and differential diagnoses aids clinicians.
  • Excisional removal is the recommended treatment as lesions do not spontaneously regress.