Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...

Alzheimer Disease l: Introduction

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology.

Nature communications·2026

Same author

Relationship between grip strength, functional outcome, and health-related quality of life measurements in amyotrophic lateral sclerosis patients.

Neurodegenerative disease management·2026

Same author

Neural Representation of Exogenous and Endogenous Temporal Expectations Based on fMRI.

CNS neuroscience & therapeutics·2026

Same author

BDNF insufficiency exacerbates ALS progression.

Cell reports. Medicine·2026

Same author

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis.

Nature genetics·2026

Same author

From Environment to Symptoms: Mapping Premorbid Risk Factors onto Clinical Features of ALS in a Patient-Reported Database in China.

Neurology and therapy·2026

Search research articles

Related Experiment Video

Updated: May 16, 2026

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

Prospective memory tasks: a more sensitive method for screening cognitive impairment in ALS?

Ying Ji¹, Ling Wei, Dehua Chui

¹Department of Neurology, Peking University Third Hospital, Beijing, China.

|November 23, 2012

Summary

Prospective memory tests are more sensitive for detecting cognitive changes in amyotrophic lateral sclerosis (ALS) patients than standard cognitive assessments. These tests can identify subtle deficits indicative of frontotemporal dysfunction in early-stage ALS.

More Related Videos

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Published on: October 13, 2016

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Related Experiment Videos

Last Updated: May 16, 2026

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Published on: October 13, 2016

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Area of Science:

Neurology
Neuropsychology
Cognitive Science

Background:

Cognitive impairment is common in amyotrophic lateral sclerosis (ALS).
A sensitive screening method for ALS-related cognitive deficits is needed.
Frontotemporal dysfunction is increasingly recognized in ALS.

Purpose of the Study:

To identify a sensitive screening battery for subtle cognitive deficits in ALS patients.
To evaluate the utility of prospective memory tests in ALS cognitive assessment.

Main Methods:

Eighty ALS patients and 57 controls completed cognitive tests.
Tests included Mini-Mental Status Examination (MMSE), verbal fluency (VFT), Stroop Color Word Interference Test (CWT).
Prospective memory (PM) tests, event-based (EBPM) and time-based (TBPM), were administered.

Main Results:

No significant differences were found in MMSE, VFT, or CWT between ALS patients and controls.
Significant differences were observed in PM tests (EBPM: P=0.043; TBPM: P<0.001).
Time-based PM (TBPM) demonstrated higher sensitivity than event-based PM (EBPM), especially in early-phase patients.

Conclusions:

Prefrontal lobar dysfunction is present in ALS patients.
Cognitive deficits in ALS may originate in medial and spread to lateral prefrontal regions.
Prospective memory tests are more sensitive than traditional measures for detecting frontotemporal dysfunction in ALS.