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Host-range modifications of bacteriophage epsilon 15
I Sechter1, R Sechter-Mooreville
1Central Laboratories, Ministry of Health, Jerusalem, Israel.
Archives of Virology
|January 1, 1990
Summary
Bacteriophage epsilon 15 showed host-range modifications when grown on Salmonella. Different Salmonella serovars exhibited varied sensitivities to these modified phages.
Area of Science:
- Microbiology
- Virology
- Bacteriology
Background:
- Bacteriophages, viruses that infect bacteria, can exhibit host-range properties.
- Salmonella serovars are important in food safety and public health.
- Understanding phage-host interactions is crucial for phage therapy and diagnostics.
Purpose of the Study:
- To investigate host-range modifications of bacteriophage epsilon 15.
- To analyze the interaction patterns between modified phage epsilon 15 and various Salmonella serovars.
Main Methods:
- Multiplication of bacteriophage epsilon 15 on Salmonella strains from five serovars.
- Testing of resulting phage preparations at routine test dilution (RTD) against strains within the same serovars.
Main Results:
- Observed host-range modifications in bacteriophage epsilon 15 after propagation.
- Identified three distinct reaction patterns in Salmonella serovars: specific sensitivity, broad sensitivity to modified phages, and complete insensitivity.
Conclusions:
- Bacteriophage epsilon 15 can adapt its host range to different Salmonella serovars.
- Salmonella serovars display differential susceptibility to modified phages, indicating complex interactions.