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Updated: May 16, 2026

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment
Published on: March 11, 2021
[An elderly woman with stiffness of the thumb]
Laurens E Franssen1, Marcel J A M Franssen, Maurice E C Jeurissen
1St. Antonius Ziekenhuis, afd. Interne Geneeskunde, Nieuwegein, the Netherlands. franssen.laurens@gmail.com
Abstract:
A 81-year-old woman presented with progressive pain, stiffness and swelling of the right thumb. She also complained of dysphagia and Raynaud's phenomenon. Physical examination revealed sclerodactyly and telangiectasia. A plain X-ray showed marked calcifications of the flexor tendon of the right thumb and esophagography demonstrated decreased motility of the lower esophagus. Additionally, anticentromere antibodies were positive. As a result, the patient was diagnosed with calcinosis as a presenting symptom of limited systemic scleroderma.
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