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Updated: May 16, 2026
10:28
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Hepatitis E virus outbreak in monkey facility, Japan
Hiroshi Yamamoto1, Juri Suzuki, Atsushi Matsuda
1University of Toyama, Toyama, Japan
Emerging Infectious Diseases
|November 23, 2012
Abstract:
An outbreak of hepatitis E virus occurred in an outdoor monkey breeding facility in Japan during 2004-2006. Phylogenetic analysis indicated that this virus was genotype 3. This virus was experimentally transmitted to a cynomolgus monkey. Precautions should be taken by facility personnel who work with monkeys to prevent infection.
Insights
Hepatitis E virus (HEV) genotype 3 caused an outbreak in a Japanese monkey facility. Researchers experimentally transmitted the virus to a cynomolgus monkey, highlighting risks for facility workers.
Area of Science:
- Virology
- Zoonotic Diseases
- Primate Health
Background:
- An outbreak of Hepatitis E virus (HEV) occurred in an outdoor monkey breeding facility in Japan between 2004 and 2006.
- The virus was identified as genotype 3, a common genotype in both humans and animals.
Purpose of the Study:
- To characterize the HEV strain responsible for the outbreak.
- To investigate the potential for zoonotic transmission from monkeys to humans.
Main Methods:
- Phylogenetic analysis of the HEV isolates from the outbreak.
- Experimental transmission of the identified HEV strain to a cynomolgus monkey.
Main Results:
- Phylogenetic analysis confirmed the HEV strain as genotype 3.
- Successful experimental transmission of the HEV genotype 3 to a cynomolgus monkey was achieved.
Conclusions:
- The HEV genotype 3 strain circulating in the monkey facility poses a zoonotic risk.
- Facility personnel working with monkeys require precautions to prevent HEV infection.
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