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Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
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Arboviral Encephalitis

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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
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Published on: June 26, 2020

Hepatitis E virus outbreak in monkey facility, Japan.

Hiroshi Yamamoto1, Juri Suzuki, Atsushi Matsuda

  • 1University of Toyama, Toyama, Japan

Emerging Infectious Diseases
|November 23, 2012
PubMed
Summary

Hepatitis E virus (HEV) genotype 3 caused an outbreak in a Japanese monkey facility. Researchers experimentally transmitted the virus to a cynomolgus monkey, highlighting risks for facility workers.

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Area of Science:

  • Virology
  • Zoonotic Diseases
  • Primate Health

Background:

  • An outbreak of Hepatitis E virus (HEV) occurred in an outdoor monkey breeding facility in Japan between 2004 and 2006.
  • The virus was identified as genotype 3, a common genotype in both humans and animals.

Purpose of the Study:

  • To characterize the HEV strain responsible for the outbreak.
  • To investigate the potential for zoonotic transmission from monkeys to humans.

Main Methods:

  • Phylogenetic analysis of the HEV isolates from the outbreak.
  • Experimental transmission of the identified HEV strain to a cynomolgus monkey.

Main Results:

  • Phylogenetic analysis confirmed the HEV strain as genotype 3.
  • Successful experimental transmission of the HEV genotype 3 to a cynomolgus monkey was achieved.

Conclusions:

  • The HEV genotype 3 strain circulating in the monkey facility poses a zoonotic risk.
  • Facility personnel working with monkeys require precautions to prevent HEV infection.