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Related Experiment Video

Updated: May 16, 2026

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Nrf2 expression is associated with poor outcome in osteosarcoma.

Jae-Young Park¹, Youn Wha Kim, Yong-Koo Park

¹Department of Pathology, Graduate School of Medicine, Kyung Hee University, Seoul, Korea.

|November 23, 2012

Summary

Increased NF-E2-related factor 2 (Nrf2) expression in osteosarcoma correlates with a poor prognosis and reduced disease-free survival. This finding suggests Nrf2 may serve as a potential biomarker for adverse outcomes in osteosarcoma patients.

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A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

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RNA Fluorescence In Situ Hybridization for Long Non-Coding RNA Localization in Human Osteosarcoma Cells

RNA Fluorescence In Situ Hybridization for Long Non-Coding RNA Localization in Human Osteosarcoma Cells

Published on: June 16, 2023

Area of Science:

Oncology
Molecular Biology
Cellular Biology

Background:

NF-E2-related factor 2 (Nrf2) is crucial for cellular defense against oxidative stress.
Overexpression of Nrf2 is observed in various cancers, implicating its role in carcinogenesis and chemoresistance.

Purpose of the Study:

To investigate the expression of Nrf2 in osteosarcoma.
To determine the prognostic significance of Nrf2 expression in osteosarcoma patients.

Main Methods:

Immunohistochemistry was employed to assess Nrf2 expression in 58 osteosarcoma specimens.
Clinicopathological parameters were analyzed for associations with Nrf2 expression levels.

Main Results:

Nrf2 was expressed in 32.8% of osteosarcoma specimens.
Nrf2 expression was significantly associated with a poor prognosis (p=0.0074) and worse disease-free survival (p=0.0279).
A higher rate of Nrf2 expression was observed in the non-osteoblastic subtype compared to the osteoblastic subtype (p=0.042).

Conclusions:

Elevated Nrf2 expression is linked to adverse outcomes and diminished disease-free survival in osteosarcoma.
Nrf2 may function as a prognostic marker for poor outcomes in osteosarcoma.