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Related Experiment Video

Updated: May 16, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Digitally programmable microfluidic automaton for multiscale combinatorial mixing and sample processing.

Erik C Jensen1, Amanda M Stockton, Thomas N Chiesl

  • 1Biophysics Graduate Group, University of California, Berkeley, CA, USA.

Lab on a Chip
|November 23, 2012
PubMed
Summary
This summary is machine-generated.

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A new microfluidic Automaton offers programmable, multiscale sample processing. This digital system enables rapid reagent mixing and complex assay automation for diverse analytical applications.

Area of Science:

  • Microfluidics
  • Automation Engineering
  • Analytical Chemistry

Background:

  • Microfluidic devices offer precise control over small fluid volumes.
  • Automating complex assays is crucial for high-throughput analysis and reduced human error.

Purpose of the Study:

  • To develop a digitally programmable microfluidic Automaton for multiscale mixing and sample processing.
  • To demonstrate automated complex assay protocols, including serial dilution and on-chip derivatization.

Main Methods:

  • A 2D array of pneumatically actuated microvalves was programmed for precise reagent metering and transfer.
  • Novel combining valve concepts were employed for rapid, complete reagent mixing (<800 ms).
  • Combinatorial implementation of unit operations (mixing, transfer, storage, rinsing) enabled assay automation.

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Digital Microfluidics for Automated Proteomic Processing
10:55

Digital Microfluidics for Automated Proteomic Processing

Published on: November 6, 2009

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Last Updated: May 16, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Digital Microfluidics for Automated Proteomic Processing
10:55

Digital Microfluidics for Automated Proteomic Processing

Published on: November 6, 2009

Main Results:

  • Demonstrated automated serial dilution for quantitative analysis.
  • Achieved the first on-chip fluorescent derivatization of carboxylic acids for microchip capillary electrophoresis on the Mars Organic Analyzer.
  • Developed a novel microfluidic 6-sample processor for combinatorial reagent mixing (>2^6 combinations).

Conclusions:

  • The digitally programmable microfluidic Automaton is a versatile platform for various sample volumes and analyses.
  • This technology facilitates complex assay automation and combinatorial processing for multiple samples.
  • The developed system advances automated sample preparation for applications like planetary exploration (Mars Organic Analyzer).