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Experimental Infection of Mice with the Parasitic Nematode Strongyloides ratti
Published on: January 17, 2025
[A case of steroid-induced hyperinfective strongyloidiasis with bacterial meningitis]
Joo Yun Cho1, Joong Goo Kwon, Kyung Ho Ha
1Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
Abstract:
Strongyloides stercoralis is a soil transmitted intestinal nematode that is endemic in the tropical and subtropical regions. In most individuals who are infected, chronic, usually asymptomatic, gastrointestinal infection persists. But, in immunocompromized hosts or in patients receiving immunosuppressive therapy, autoinfection of S. stercoralis may result in the dissemination of larvae, leading to fatal hyperinfection and increased rate of complications. We report a case of hyperinfective strongyloidiasis with bacterial meningitis in a patient receiving steroid therapy. Strongyloidiasis was diagnosed by the presence of filariform larvae of S. stercoralis in the bronchoalveolar lavage cytology and upper gastrointestinal endoscopic biopsy specimen. Her clinical symptoms had progressively aggravated and developed bacterial meningitis during treatment. She died despite aggressive antibiotic and antihelminthic therapy.
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