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Updated: May 16, 2026

High-throughput Measurement of Dictyostelium discoideum Macropinocytosis by Flow Cytometry
Published on: September 10, 2018
DictyBase 2013: integrating multiple Dictyostelid species
Siddhartha Basu1, Petra Fey, Yogesh Pandit
1Biomedical Informatics Center and Center for Genetic Medicine, Northwestern Univesity, Feinberg School of Medicine, 750 North Lake Shore Drive, Chicago, IL 60611, USA.
dictyBase has expanded to become a genome portal for Amoebozoa, now including multiple Dictyostelid species. The updated database features a new Genome Browser with RNAseq expression and cross-species comparison tools.
Area of Science:
- Bioinformatics
- Genomics
- Computational Biology
Background:
- dictyBase is the primary model organism database for Dictyostelium discoideum.
- Previous updates have focused on expanding its capabilities and data scope.
Purpose of the Study:
- To provide an update on the advancements and new features of dictyBase.
- To highlight dictyBase's evolution into a genome portal for the Amoebozoa clade.
Main Methods:
- Integration of multiple Dictyostelid genomes, including Dictyostelium purpureum, Dictyostelium fasciculatum, and Polysphondylium pallidum.
- Development of a new Genome Browser incorporating RNAseq expression data.
- Implementation of interspecies Basic Local Alignment Search Tool (BLAST) alignments and a unified BLAST search functionality.
Main Results:
- dictyBase now hosts an expanded collection of Dictyostelid genomes.
- The new Genome Browser offers visualization of RNAseq expression data.
- Enhanced cross-species comparison capabilities are available through integrated BLAST tools.
Conclusions:
- dictyBase has significantly advanced its role as a comprehensive genome portal for the Amoebozoa.
- The new features facilitate deeper comparative genomic analysis within the Amoebozoa clade.
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