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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
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Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

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LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
Lampbrush Chromosomes01:51

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In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
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Genomics02:02

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

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A Web Tool for Generating High Quality Machine-readable Biological Pathways
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Scribl: an HTML5 Canvas-based graphics library for visualizing genomic data over the web.

Chase A Miller1, Jon Anthony, Michelle M Meyer

  • 1Department of Biology, Boston College, Chestnut Hill, MA 02467, USA.

Bioinformatics (Oxford, England)
|November 23, 2012
PubMed
Summary
This summary is machine-generated.

Scribl is a new JavaScript library for creating interactive, web-based genomic data visualizations. It enables sophisticated analysis and viewing of large, remote datasets, simplifying complex biological research.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomic Data Visualization

Background:

  • High-throughput biological research necessitates integrated visualization and analysis of genomic data like read alignments and variant calls.
  • Traditional desktop applications struggle with the increasing size of genomic datasets, often stored remotely.
  • Web-based tools are needed to provide sophisticated, interactive access to large, remote genomic datasets.

Purpose of the Study:

  • To develop a flexible, web-based library for visualizing coordinate-based genomic data.
  • To simplify the creation of dynamic and interactive graphical tools for genomic analysis.
  • To empower scientists with customized data analysis and viewing capabilities for specialized biological questions.

Main Methods:

  • Developed Scribl, a library using HTML5 and JavaScript.
  • Targeted coordinate-based genomic data, including features, DNA sequence, and genetic variants.
  • Ensured compatibility with all modern web browsers.

Main Results:

  • Scribl facilitates the development of sophisticated web-based graphical tools.
  • The library offers dynamism and interactivity comparable to desktop applications.
  • Enables visualization of genomic features, DNA sequence, and genetic variants.

Conclusions:

  • Scribl provides a flexible solution for web-based genomic data visualization.
  • The library simplifies the creation of advanced, interactive tools for researchers.
  • Addresses the growing need for accessible analysis of large, remote genomic datasets.