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Updated: May 16, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
Published on: March 29, 2018
[Effect to demineralization and remineralization of enamel surface by fluorine]
Na Wu1, Xuedong Zhou, Yuqing Hao
1Dept. of Conservative Dentistry and Endodontics, The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing Research Center for Oral Diseases and Biomedical Science, Chongqing 401147, China.
Objective:
To analyze the mechanism of fluorine by systemic analysis of fluorination-demineralization-remineralization experiments.
Methods:
The enamel specimens were randomly assigned to untreated group (group A), non-fluoride group (group B), low-fluoride group (group C) and high-fluoride group (group D). The in vitro model of fluoride enamel was established in group C and D. Based on that, the establishment of demineralization model and remineralization experiment by pH-cycling in group B, C and D were followed. All enamel specimens were observed by stereomicroscope and scanning electron microscope and compared in surface microhardness value.
Results:
There was distinct difference in micro-morphologic appearance on fluoride enamel surface. Artificial caries of fluoride enamel showed a relatively complete surface, the surface microhardness after demineralization and remineralization in fluoride group was higher than non-fluoride group (P < 0.05).
Conclusion:
The fluorinated enamel can enhance cariostatic potential and remineralization capacity of dental enamel.
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