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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
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Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...

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Updated: May 16, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

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Published on: August 12, 2020

Plasma-mediated immune suppression: a neonatal perspective.

Mirjam E Belderbos1, Ofer Levy, Linde Meyaard

  • 1University Medical Center Groningen, Groningen, The Netherlands. m.belderbos@umcutrecht.nl

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|November 24, 2012
PubMed
Summary

Neonatal plasma contains factors that suppress immune responses, offering a unique window into immune regulation. These findings may lead to new treatments for immune-mediated diseases.

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Area of Science:

  • Immunology
  • Neonatal Medicine

Background:

  • Plasma contains immune regulatory factors crucial for immune cell function.
  • The neonatal immune system is biased towards immune suppression to ensure feto-maternal tolerance and microbial colonization.
  • The neonatal period offers a unique model for studying immune system regulation.

Purpose of the Study:

  • To review plasma-mediated immune regulation, with a focus on neonatal plasma.
  • To systematically overview plasma-derived immune suppressive factors.
  • To explore the potential clinical applications of these factors in treating immune-mediated diseases.

Main Methods:

  • Systematic literature review of plasma-derived immune suppressive proteins, lipids, purines, and sugars.
  • Focus on studies involving neonatal plasma and its immunomodulatory effects.

Main Results:

  • Plasma plays a key role in immune suppression.
  • Specific plasma factors, including proteins, lipids, purines, and sugars, contribute to immune regulation.
  • These factors are particularly abundant in neonatal plasma.

Conclusions:

  • Neonatal plasma exhibits significant immune-suppressive properties.
  • Understanding these plasma-derived factors can inform the development of novel therapies for autoimmune, allergic, and inflammatory diseases.
  • Plasma's accessibility and affordability make it a promising source for therapeutic immune modulation.