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Updated: May 16, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
Natural history and clinical response: "it's the virus, stupid, or is it the host?"
Stefania Nucara1, Benedetto Caroleo, Vincenzo Guadagnino
1Unità Operativa di Genetica Medica, Policlinico Universitario Mater Domini, Università Magna Græcia di Catanzaro, Campus S, Venuta, 88100 Catanzaro, Italy.
Abstract:
A major goal of modern medicine is the application of personalized therapies, consisting of decisions and practices tailored to the individual patient. Information about genetic variants, either mutant or polymorphic, represents the basis for the development of this clinical approach. Recently, several independent genome-wide association studies (GWAS) have identified two single nucleotide polymorphisms (SNPs) on the IL28B locus associated with HCV containment, spontaneous clearance, treatment response, and disease progression. In this minireview we will concisely discuss some critical genetic concepts that may have possible implications for clinical decisions in the treatment of HCV infection.
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