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miR-210: a therapeutic target in cancer
Liu Hong1, Yu Han, Hongwei Zhang
1Fourth Military Medical University, Xijing Hospital of Digestive Diseases, Xijing Hospital, State Key Laboratory of Cancer Biology, Xi'an, 710032, Shaanxi Province, China. hongliu180@126.com
Introduction:
As the predominant miRNA regulated by hypoxia, miR-210 correlates with survival in cancer patients. miR-210 may play important roles in regulation of cell growth, angiogenesis and apoptosis in different human tumor models, indicating that it can be used as a therapeutic target.
Areas Covered:
This review covers all literature related to miR-210 in malignant tumors from the past 5 years, and analyzes the biological functions and molecular mechanisms of it. The authors also envisage future developments toward the clinical applications of miR-210 to cancer diagnosis and treatment.
Expert Opinion:
miR-210 may function as a new therapeutic target for anticancer intervention. Considering that the exact function of miR-210 is still not well characterized and understood, more investigations should be performed to promote the success of therapeutic-clinical use of miR-210 in cancer.
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