Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enhanced thromboxane synthesis with extradural anaesthesia.

A Khazam1, J M Klausner, S Lelcuk

  • 1Department of Anaesthesiology, Rokach Hospital, Tel Aviv, Israel.

British Journal of Anaesthesia
|February 1, 1990
PubMed
Summary

Extradural anesthesia, unlike general anesthesia, significantly increases thromboxane (TxB2) production during femoral artery clamping in bypass surgery. This suggests extradural anesthesia maintains blood flow, providing oxygen for TxB2 synthesis during ischemia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Timing of colostomy reversal following Hartmann's procedure for perforated diverticulitis.

Journal of visceral surgery·2020
Same author

Solid pseudopapillary neoplasm of the pancreas: Management and long-term outcome.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2017
Same author

Number of evaluated lymph nodes and positive lymph nodes, lymph node ratio, and log odds evaluation in early-stage pancreatic ductal adenocarcinoma: numerology or valid indicators of patient outcome?

World journal of surgical oncology·2016
Same author

Does residual microscopic disease after chemoradiotherapy for locally advanced rectal cancer translate into a good clinical outcome?

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2016
Same author

Clinical recurrence and re-resection rates after extensive vs. segmental colectomy in Crohn's colitis: a retrospective cohort study.

Techniques in coloproctology·2016
Same author

Doppler ultrasound for the assessment of conservatively treated blunt splenic injuries: a prospective study.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2016

Area of Science:

  • Vascular Surgery
  • Anesthesiology
  • Biochemistry

Background:

  • Tourniquet ischemia and subsequent reperfusion elevate plasma thromboxane B2 (TxB2) levels.
  • Thromboxane B2 plays a role in vascular homeostasis and platelet aggregation.

Purpose of the Study:

  • To investigate TxB2 production during femoral-popliteal bypass surgery under different anesthetic techniques.
  • To determine the impact of general anesthesia (GA) versus extradural anesthesia (EA) on TxB2 levels during ischemia and reperfusion.

Main Methods:

  • A randomized study involving 19 patients undergoing femoral-popliteal bypass surgery, allocated to GA or EA.
  • Measurement of TxB2 concentrations before, during, and after femoral artery clamping.
  • A control group (n=13) undergoing inguinal herniorrhaphy received either GA or EA to assess anesthesia's direct effect on TxB2.

Related Experiment Videos

Main Results:

  • Femoral artery clamping in the EA group led to a significant 10-fold increase in TxB2 concentrations (P < 0.05).
  • In contrast, clamping in the GA group resulted in only a small, insignificant increase in TxB2.
  • No significant changes in TxB2 were observed in the control herniorrhaphy group regardless of anesthetic technique.

Conclusions:

  • Extradural anesthesia, but not general anesthesia, appears to maintain collateral blood flow during femoral artery clamping.
  • This preserved blood flow under EA provides the necessary oxygen for thromboxane B2 generation during the ischemic period.