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The eosinophil granulocyte in psoriasis.

A Lundin¹, K Fredens, G Michaëlsson

¹Department of Dermatology, University Hospital, Uppsala, Sweden.

The British Journal of Dermatology

|February 1, 1990

Summary

Eosinophils and eosinophil cationic protein (ECP) are present in psoriasis skin lesions. Elevated ECP levels in skin and blister fluid correlate with disease activity, suggesting a role in psoriasis pathogenesis.

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Area of Science:

Dermatology
Immunology
Pathology

Background:

Psoriasis is a chronic inflammatory skin disease.
The role of eosinophils in psoriasis is not fully understood.

Purpose of the Study:

To investigate the presence and significance of eosinophils and eosinophil cationic protein (ECP) in psoriatic skin lesions.
To correlate ECP levels with disease activity and progression.

Main Methods:

Immunohistochemical analysis using antibodies against ECP and activated eosinophils (EG2) on skin biopsies from involved and non-involved psoriatic skin.
Quantification of ECP in suction-blister fluid from lesional and non-lesional skin of psoriasis patients and healthy controls.

Main Results:

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ECP-immunoreactive eosinophils were detected in all involved psoriatic skin specimens.

Intense intra- and extracellular ECP immunoreactivity was observed in new lesions of rapidly progressive psoriasis, often near granulocytes.

EG2 immunoreactivity confirmed the presence of activated eosinophils in similar locations.

ECP concentrations were significantly elevated in blister fluid from active psoriatic lesions compared to non-involved skin and healthy controls.

Lower ECP levels were noted in stable or slowly progressive lesions.

Conclusions:

Eosinophils and their product, ECP, are significantly involved in the inflammatory process of psoriasis.
Elevated ECP levels in skin and blister fluid are associated with acute and progressive psoriatic disease.
These findings suggest ECP may play a role in the pathogenesis of psoriasis and could be a potential biomarker for disease activity.