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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...

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Related Experiment Video

Updated: May 16, 2026

Application of Consistent Massage-Like Perturbations on Mouse Calves and Monitoring the Resulting Intramuscular Pressure Changes
07:49

Application of Consistent Massage-Like Perturbations on Mouse Calves and Monitoring the Resulting Intramuscular Pressure Changes

Published on: September 20, 2019

Exercise in muscle pain disorders.

Jeffrey M Thompson1

  • 1Department of Physical Medicine and Rehabilitation, Mayo School of Graduate Medical Education, 200 1st St SW, Rochester, MN 55905-0001, USA. thompson.jeffrey@mayo.edu

PM & R : the Journal of Injury, Function, and Rehabilitation
|November 24, 2012
PubMed
Summary

Exercise is a highly effective treatment for muscle pain disorders like myofascial pain and fibromyalgia. Carefully designed exercise programs offer benefits comparable to medication for managing these conditions.

More Related Videos

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
08:33

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Published on: December 11, 2016

Related Experiment Videos

Last Updated: May 16, 2026

Application of Consistent Massage-Like Perturbations on Mouse Calves and Monitoring the Resulting Intramuscular Pressure Changes
07:49

Application of Consistent Massage-Like Perturbations on Mouse Calves and Monitoring the Resulting Intramuscular Pressure Changes

Published on: September 20, 2019

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
08:33

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Published on: December 11, 2016

Area of Science:

  • Pain management
  • Musculoskeletal disorders
  • Physical therapy

Background:

  • Muscle pain disorders encompass local (myofascial pain) and widespread (fibromyalgia) conditions.
  • Individuals with muscle pain often experience reduced physical fitness and exercise intolerance.
  • Despite challenges, exercise is crucial for managing muscle pain disorders.

Purpose of the Study:

  • To highlight the critical role of exercise in treating muscle pain disorders.
  • To emphasize that exercise is as effective as pharmacological treatments.
  • To promote understanding of exercise benefits for clinicians and patients.

Main Methods:

  • Review of existing study results on exercise interventions for muscle pain.
  • Analysis of various exercise modes and delivery methods.
  • Comparison of exercise efficacy against pharmacologic treatments.

Main Results:

  • Exercise has been repeatedly shown to be effective in treating muscle pain disorders.
  • Exercise interventions demonstrate efficacy comparable to leading pharmacologic treatments.
  • Multiple study modes and delivery methods confirm exercise's effectiveness.

Conclusions:

  • Exercise is a cornerstone treatment for myofascial pain and fibromyalgia.
  • A well-structured exercise program is vital for successful management.
  • Educating clinicians and patients on exercise benefits is key to improving outcomes.