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Related Concept Videos

Microscopic Anatomy of Skeletal Muscles01:13

Microscopic Anatomy of Skeletal Muscles

Skeletal muscle cells, also called muscle fibers, are distinctly elongated, multi-nucleated, slender biological units. They are packed with specialized structures designed to facilitate their primary function, which is contraction.
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Related Experiment Video

Updated: May 16, 2026

Semi-automated Analysis of Mouse Skeletal Muscle Morphology and Fiber-type Composition
08:36

Semi-automated Analysis of Mouse Skeletal Muscle Morphology and Fiber-type Composition

Published on: August 31, 2017

String mitochondria in mouse soleus muscle.

Hisashi Fujioka1, Bernard Tandler, Saptarsi M Haldar

  • 1Electron Microscopy Facility, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA. hisashi.fujioka@case.edu

Microscopy Research and Technique
|November 24, 2012
PubMed
Summary
This summary is machine-generated.

Mouse soleus muscle red myofibers contain two distinct mitochondrial populations. Interfibrillar mitochondria (IFM) can fuse into elongated "string mitochondria," suggesting a fusion-fission imbalance.

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Isolation of Mitochondria from Mouse Skeletal Muscle for Respirometric Assays
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Isolation of Mitochondria from Mouse Skeletal Muscle for Respirometric Assays

Published on: February 10, 2022

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Last Updated: May 16, 2026

Semi-automated Analysis of Mouse Skeletal Muscle Morphology and Fiber-type Composition
08:36

Semi-automated Analysis of Mouse Skeletal Muscle Morphology and Fiber-type Composition

Published on: August 31, 2017

Isolation of Mitochondria from Mouse Skeletal Muscle for Respirometric Assays
08:11

Isolation of Mitochondria from Mouse Skeletal Muscle for Respirometric Assays

Published on: February 10, 2022

Area of Science:

  • Muscle physiology
  • Cell biology
  • Mitochondrial dynamics

Background:

  • Red myofibers in mouse soleus muscle exhibit unique mitochondrial organization.
  • Mitochondria exist as subsarcolemmal (SSM) clusters and interfibrillar (IFM) structures.

Purpose of the Study:

  • To investigate the morphology and arrangement of mitochondria in mouse soleus red myofibers.
  • To explore the phenomenon of "string mitochondria" and their relationship with mitochondrial division.

Main Methods:

  • Light microscopy of mouse soleus muscle cross-sections.
  • Morphological analysis of mitochondrial populations (SSM and IFM).

Main Results:

  • Two distinct mitochondrial populations were identified: subsarcolemmal (SSM) and interfibrillar (IFM).
  • IFM, smaller than SSM, are often paired around Z-lines.
  • Some IFM fuse end-to-end forming elongated "string mitochondria," which exhibit "pinching" indicative of division.
  • Sarcoplasmic reticulum interacts closely with mitochondrial membranes.

Conclusions:

  • Mouse soleus red myofibers display specialized mitochondrial arrangements.
  • The formation of string mitochondria suggests a fusion-predominant state in IFM dynamics.
  • Mitochondrial fusion and fission balance may be altered in these muscle fibers.