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Updated: May 16, 2026

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
Published on: July 25, 2017
Human tumour viruses and the deregulation of cell polarity in cancer
Lawrence Banks1, David Pim, Miranda Thomas
1The International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34149 Trieste, Italy. Banks@icgeb.org
Abstract:
The role of cell polarity regulators in the development of cancer has long been an enigma. Despite displaying characteristics of tumour suppressors, the core regulators of polarity are rarely mutated in tumours and there are few data from animal models to suggest that they directly contribute to cancer susceptibility, thus questioning their relevance to human carcinogenesis. However, a body of data from human tumour viruses is now providing compelling evidence of a central role for the perturbation of cell polarity in the development of cancer.
Insights
Cell polarity regulators are crucial in cancer development. Human tumor viruses reveal that disrupting cell polarity plays a central role in human carcinogenesis, challenging previous assumptions.
Area of Science:
- Cell Biology
- Oncology
- Virology
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