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Updated: May 16, 2026

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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Development and evaluation of a novel, semiautomated Clostridium difficile typing platform
Lars F Westblade1, Robin R Chamberland, Duncan MacCannell
1Department of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
Journal of Clinical Microbiology
|November 24, 2012
Abstract:
We describe a novel, semiautomated Clostridium difficile typing platform that is based on PCR-ribotyping in conjunction with a semiautomated molecular typing system. The platform is reproducible with minimal intra- or interassay variability. This method exhibited a discriminatory index of 0.954 and is therefore comparable to more arduous typing systems, such as pulsed-field gel electrophoresis.
