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[Study on blindness: mortality of patients with chronic kidney disease during non-elective hemodialysis]
Letícia Krauss Silva1, Rachel Bregman, Dulce Lessi
1Departamento de Administração e Planejamento em Saúde, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, Rua Leopoldo Bulhões 1480/714, Manguinhos, 21041210 Rio de Janeiro RJ, Brazil. leticiak@ensp.fiocruz.br
Insights
Many patients with chronic kidney disease (CKD) die before receiving dialysis, highlighting poor access to secondary prevention. Early arteriovenous fistula creation significantly reduces mortality risk in CKD patients.
Area of Science:
- Nephrology
- Public Health
Context:
- Chronic kidney disease (CKD) is a progressive condition leading to renal failure and the need for renal replacement therapy (RRT).
- Secondary prevention strategies are crucial for delaying CKD progression.
- Access to timely RRT and preventative care remains a challenge in many regions.
Purpose:
- To analyze prognostic factors and estimate mortality in CKD patients with diabetes or hypertension initiating RRT via non-elective hemodialysis.
- To evaluate the impact of age and arteriovenous fistula presence on mortality.
- To identify gaps in secondary prevention for CKD.
Summary:
- This retrospective study analyzed 35.1% mortality in CKD patients undergoing non-elective hemodialysis.
- Disease etiology and functional arteriovenous fistulae significantly impacted survival.
- Older age increased mortality risk, while functional fistulae reduced it substantially.
Impact:
- Findings indicate a critical deficit in secondary CKD prevention, including timely arteriovenous fistula creation.
- Approximately one-third of patients initiating RRT via non-elective hemodialysis die before transfer to specialized units.
- Highlights the urgent need for improved access to preventative care and vascular access for CKD patients.
Abstract:
Chronic kidney disease (CKD) leads to renal failure and the need for renal replacement therapy (RRT). Secondary prevention may postpone CKD for many years. This retrospective study sought to analyze prognostic factors and estimate the mortality of patients with CKD secondary to diabetes mellitus and to hypertension that initiate RRT through non-elective hemodialysis at an emergency hospital unit in Rio de Janeiro, from hospital admission until transfer to referral units. The mortality rate was 35.1%. The study detected a significant difference between the survival curves according to disease etiology (log-rank and Peto, p=0.02) and the presence of functional arteriovenous fistulae (log-rank, p=0.0099; Peto, p=0.0090). Multivariate analysis (Cox model) revealed a 7% increase in the risk of death (p=0.002) by one-year increment in age; the presence of a functional fistule was associated to an 81% reduction in the risk of death (p=0.03). About one third of patients with CKD followed by hypertension or diabetes that initiate renal replacement therapy through non-elective hemodialysis die before being transferred to a referral unit, indicating low access to secondary prevention in CKD, including surgery for arteriovenous fistula creation.
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