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Updated: May 16, 2026
08:18
Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model
Published on: February 8, 2022
Risk factors for intracerebral hemorrhage differ according to hemorrhage location
Sharyl R Martini1, Matthew L Flaherty, W Mark Brown
1Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Neurology
|November 24, 2012
Summary
APOE ε2 or ε4 genotype is linked to lobar intracerebral hemorrhage (ICH), while hypertension is specific to nonlobar ICH. Hypercholesterolemia shows a protective association with nonlobar ICH.
Area of Science:
- Neurology
- Genetics
- Epidemiology
Background:
- Spontaneous intracerebral hemorrhage (ICH) is a significant cause of mortality and morbidity.
- While risk factors for ICH are known, their differential impact on lobar versus nonlobar hemorrhage locations requires further investigation.
Purpose of the Study:
- To investigate and differentiate the risk factors associated with lobar and nonlobar intracerebral hemorrhage locations.
Main Methods:
- A prospective case-control study was conducted.
- Subjects with first-ever spontaneous ICH were enrolled and matched with up to three controls based on age, race, and gender.
- Conditional stepwise logistic regression modeling identified significant independent risk factors for lobar and nonlobar ICH.
Main Results:
- The study analyzed 597 ICH cases and 1,548 controls.
- Hypertension, warfarin use, family history of ICH, prior ischemic stroke, lower education, and APOE ε2 or ε4 genotype were more prevalent in ICH cases.
- Hypercholesterolemia and moderate alcohol consumption were less common in ICH cases, with associations specific to nonlobar ICH for hypertension and hypercholesterolemia, and lobar ICH for APOE ε2 or ε4 genotype.
Conclusions:
- APOE ε2 or ε4 genotype is specifically associated with lobar ICH.
- Hypertension is specifically associated with nonlobar ICH.
- Hypercholesterolemia demonstrates a protective association with nonlobar ICH, but not lobar ICH.
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