Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptional Response to Chronic Long-Access Fentanyl Self-Administration in Rat Habenula and Amygdala.

Addiction biology·2026
Same author

BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus.

Molecular psychiatry·2026
Same author

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same author

Perturbation of genes linked to common schizophrenia risk variants identifies cilia programs.

bioRxiv : the preprint server for biology·2026
Same author

Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain.

Cell reports·2026
Same author

Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: May 16, 2026

Quantitative Analysis of Neuronal Dendritic Arborization Complexity in Drosophila
07:13

Quantitative Analysis of Neuronal Dendritic Arborization Complexity in Drosophila

Published on: January 7, 2019

DSCAM contributes to dendrite arborization and spine formation in the developing cerebral cortex.

Kristen R Maynard1, Elke Stein

  • 1Department of Molecular, Cellular and Developmental Biology, Cell Biology and Interdisciplinary Neuroscience Program, Yale University, New Haven, Connecticut 06520, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 24, 2012
PubMed
Summary

Down syndrome cell adhesion molecule (DSCAM) is crucial for pyramidal neuron development in the mouse cortex. Mutations impair dendrite branching and spine formation, impacting cortical circuit development.

More Related Videos

Analysis of Dendritic Spine Morphology in Cultured CNS Neurons
11:48

Analysis of Dendritic Spine Morphology in Cultured CNS Neurons

Published on: July 13, 2011

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice
10:55

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice

Published on: March 31, 2015

Related Experiment Videos

Last Updated: May 16, 2026

Quantitative Analysis of Neuronal Dendritic Arborization Complexity in Drosophila
07:13

Quantitative Analysis of Neuronal Dendritic Arborization Complexity in Drosophila

Published on: January 7, 2019

Analysis of Dendritic Spine Morphology in Cultured CNS Neurons
11:48

Analysis of Dendritic Spine Morphology in Cultured CNS Neurons

Published on: July 13, 2011

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice
10:55

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice

Published on: March 31, 2015

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Down syndrome cell adhesion molecule (DSCAM) is known to influence neurodevelopmental processes.
  • Its specific role in the morphogenesis of cortical pyramidal neurons remains to be fully elucidated.

Purpose of the Study:

  • To investigate the role of DSCAM in regulating the morphogenesis of cortical pyramidal neurons in mice.
  • To analyze the effects of DSCAM mutations on neuronal structure and cortical development.

Main Methods:

  • Analysis of DSCAM expression patterns during cortical development.
  • Examination of brain morphology and cortical organization in mice with a spontaneous DSCAM mutation (DSCAM(del17)).
  • Assessment of dendrite arborization and spine morphology in DSCAM(del17) mutant mice at various postnatal ages.

Main Results:

  • DSCAM expression is developmentally regulated and localized to synaptic plasma membranes during critical periods of cortical development.
  • DSCAM(del17) mutant mice exhibit altered brain size, shape, and cortical organization, including transient reductions in cortical thickness.
  • Mutant mice show temporary deficits in pyramidal neuron dendrite branching and altered spine density and morphology, with a shift towards less mature spines.

Conclusions:

  • DSCAM plays a significant role in regulating pyramidal neuron morphogenesis, specifically influencing dendrite arborization and spine formation.
  • These findings highlight DSCAM's importance in the development of functional cortical circuits.
  • Dysregulation of DSCAM may contribute to neurodevelopmental abnormalities observed in conditions affecting cortical development.