Related Experiment Video
Updated: May 16, 2026
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Neutrophil-lymphocyte ratio predicts graft patency following lower limb revascularisation
P Kullar1, R Weerakoddy, S Walsh
1Vascular Surgery Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, U.K. peterkullar@doctors.org.uk
Background:
Graft failure is a significant problem following lower limb revascularisation. We hypothesised that the neutrophil-lymphocyte ratio (NLR), a simple and inexpensive index of systemic inflammation, predicts graft failure.
Methods:
Consecutive patients undergoing infra-inguinal bypass grafting were identified from a prospective database. All patients underwent routine graft surveillance using Duplex ultrasound. Potential predictors of graft failure (occlusion or ipsilateral amputation) were assessed in univariate and multivariate regression models.
Results:
Of 126 patients, 79 had patent grafts at 1 year. The only independent predictor of graft failure was the postoperative NLR.
Conclusion:
Post-operative NLR may be a simple, inexpensive means of focussing surveillance resources on patients at high-risk of graft failure. Its value needs to be confirmed in larger cohorts.
