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Published on: November 28, 2019
Purinergic signalling in the lower urinary tract
1Autonomic Neuroscience Centre, University College Medical School, London, UK. g.burnstock@ucl.ac.uk
Acta Physiologica (Oxford, England)
|November 27, 2012
Summary
Purinergic signaling, involving adenosine triphosphate (ATP), is crucial for the lower urinary tract
Area of Science:
- Urology
- Neuroscience
- Cell Biology
Background:
- Purinergic signaling, mediated by adenosine triphosphate (ATP) and its receptors, plays a significant role in the lower urinary tract's function.
- ATP acts as a neurotransmitter and signaling molecule, influencing bladder function, sensory pathways, and pain perception.
- Dysregulation of purinergic signaling is implicated in various lower urinary tract disorders.
Purpose of the Study:
- To review the conceptual development of purinergic signaling knowledge.
- To explore the role of purinergic signaling in lower urinary tract physiology and pathophysiology.
- To discuss the potential therapeutic applications of targeting purinergic pathways.
Main Methods:
- Literature review of studies on purinergic signaling in the lower urinary tract.
- Analysis of the involvement of ATP and its receptors (P2X3, P2X5, P2X7) in physiological processes.
- Examination of evidence for purinergic signaling in bladder distension, pain, and cancer treatment.
Main Results:
- ATP released from nerves and urothelial cells initiates the voiding reflex via P2X3 receptors.
- Purinergic signaling contributes to mechanosensory transduction and pain initiation in the bladder and ureter.
- ATP demonstrates efficacy against prostate and bladder cancer in preclinical models via P2X5 and P2X7 receptors.
Conclusions:
- Purinergic signaling is a key regulator of lower urinary tract function, including the voiding reflex and pain pathways.
- Targeting purinergic receptors offers potential therapeutic strategies for lower urinary tract disorders and cancers.
- Further research into purinergic mechanisms may elucidate treatments like acupuncture for urinary conditions.
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