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Published on: July 19, 2018
Intensification of peritoneal dialysis improves valacyclovir neurotoxicity
Chrysoula Pipili1, Kostas Pantelias, Edmond Deda
1Department of Nephrology, Aretaieion University Hospital, Athens, Greece. chrysapi2001@gmail.com
Abstract:
Valacyclovir induced neurotoxicity is a life-threatening complication, usually starting 24-48 h after drug-peak serum concentrations. The elderly with impaired renal function seem to be the most susceptible group to valacyclovir neurotoxicity. Although hemodialysis is considered the best method for rapid drug removal, our case showed that intensive peritoneal dialysis regimen leads to the recovery of neurotoxicity after 3 days.
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