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Anti-atherosclerotic therapy based on botanicals
Alexander N Orekhov1, Igor A Sobenin, Nikolay V Korneev
1Institute for Atherosclerosis Research of Skolkovo Innovative Center, Moscow, Russia.
Recent Patents on Cardiovascular Drug Discovery
|November 27, 2012
Summary
Long-term use of the garlic-based drug Allicor significantly reduced carotid atherosclerosis progression in men. This natural product therapy may work by inhibiting serum atherogenicity, offering a promising botanical approach to treating atherosclerosis.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Natural Products Research
Background:
- Natural products, particularly botanicals, are increasingly patented for atherosclerosis therapy and risk reduction.
- Few patents address direct anti-atherosclerotic therapy for lesion regression.
- Previous cellular models and patents have identified anti-atherosclerotic drugs.
Purpose of the Study:
- To evaluate the effect of a two-year treatment with Allicor, a time-released garlic-based drug, on carotid atherosclerosis progression.
- To assess the impact of Allicor on atherosclerosis risk factors in asymptomatic men.
- To investigate the relationship between serum atherogenicity and intima-media thickness changes.
Main Methods:
- The Atherosclerosis Monitoring and Atherogenicity Reduction (AMAR) study was a double-blinded, placebo-controlled, randomized clinical trial.
- 196 asymptomatic men aged 40-74 received either Allicor or placebo for two years.
- Carotid atherosclerosis progression was measured using high-resolution B-mode ultrasonography, assessing changes in carotid intima-media thickness (IMT).
Main Results:
- Allicor treatment resulted in a significant reduction in carotid atherosclerosis progression (mean IMT change: -0.022±0.007 mm/year) compared to placebo (0.015±0.008 mm/year) (P = 0.002).
- A significant correlation was observed between reduced serum atherogenicity and decreased intima-media thickness (r = 0.144, P = 0.045).
- The study demonstrated a direct anti-atherosclerotic effect of Allicor on carotid atherosclerosis, likely mediated by serum atherogenicity inhibition.
Conclusions:
- Long-term Allicor treatment exhibits a direct anti-atherosclerotic effect on carotid atherosclerosis.
- The therapeutic benefit of Allicor is potentially linked to the inhibition of serum atherogenicity.
- Botanicals like Allicor represent promising therapeutic agents for anti-atherosclerotic therapy, supported by findings on other botanicals like Inflaminat and Karinat.
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