Related Experiment Video
Updated: May 16, 2026
08:25
Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
Published on: September 9, 2020
Rab25 in cancer: a brief update.
Shreya Mitra1, Kwai W Cheng, Gordon B Mills
1Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston TX 77054, USA. smitra@mdanderson.org
Biochemical Society Transactions
|November 27, 2012
Summary
Rab25, a Rab GTPase, plays a complex role in cancer by affecting cellular processes like invasion and energetics. Its function as an oncogene or tumor suppressor depends on the cancer context.
Area of Science:
- Oncology
- Cell Biology
- Molecular Biology
Background:
- Derailed endocytosis is a hallmark of cancer, impacting cellular polarity, stemness, and metabolism.
- Rab GTPases regulate endocytic machinery, influencing cell growth and metabolism.
- Rab25, an epithelial-specific Rab GTPase, has been linked to cancer as both an oncogene and tumor suppressor.
Purpose of the Study:
- To provide an updated overview of the complex and context-dependent role of Rab25 in cancer.
- To synthesize current evidence on Rab25's involvement in cancer progression and cellular energetics.
Main Methods:
- Review of existing literature on Rab25 and its role in cancer.
- Analysis of Rab25's function in cellular processes including endocytosis, integrin trafficking, and bioenergetics.
Main Results:
- Rab25 regulates integrin trafficking, contributing to cancer cell invasiveness.
- Recent findings highlight Rab25's critical role in cellular energetics.
- The dual role of Rab25 (oncogene vs. tumor suppressor) is context-dependent.
Conclusions:
- Rab25's multifaceted role in cancer necessitates a nuanced understanding.
- Further research is needed to elucidate the precise mechanisms and therapeutic potential of targeting Rab25 in various cancers.
Related Concept Videos
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
02:18Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...