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Related Experiment Video

Updated: May 16, 2026

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer
11:31

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer

Published on: May 20, 2016

What causes false-negative PET findings for solid-type lung cancer?

Shingo Iwano1, Shinji Ito, Kenichi Tsuchiya

  • 1Department of Radiology, Nagoya University Graduate School of Medicine, Japan. iwano45@med.nagoya-u.ac.jp

Lung Cancer (Amsterdam, Netherlands)
|November 27, 2012
PubMed
Summary

Small solid lung cancers (≤ 2 cm) and certain histological types, like bronchioloalveolar carcinoma, are more likely to have false-negative results on PET scans, impacting lung cancer diagnosis.

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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • False-negative findings on Positron Emission Tomography (PET) scans can occur in solid-type lung cancers.
  • Investigating the reasons for these false negatives is crucial for accurate lung cancer diagnosis and staging.

Purpose of the Study:

  • To identify clinical and pathological factors associated with false-negative PET scan results in solid-type lung cancers.
  • To improve the diagnostic accuracy of PET imaging for lung malignancies.

Main Methods:

  • Retrospective analysis of 187 solid-type primary lung cancers (≤ 40 mm) diagnosed by surgical resection.
  • Comparison of PET/CT findings with clinical, thin-section CT, and pathological data.
  • Multivariate logistic regression analysis to determine predictors of PET-positive (SUVmax ≥ 2.5) or PET-negative findings.

Related Experiment Videos

Last Updated: May 16, 2026

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer
11:31

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer

Published on: May 20, 2016

Main Results:

  • 21.4% of lesions were PET-negative, while 78.6% were PET-positive.
  • Multivariate analysis identified lesion size (p<0.001) and histological tumor type (p<0.001) as significant predictors of PET negativity.
  • Lesions ≤ 2 cm, bronchioloalveolar carcinoma, and well-differentiated adenocarcinoma showed a tendency for negative PET findings.

Conclusions:

  • Lesion size and histopathological findings are significantly associated with Fluorodeoxyglucose (FDG) uptake in solid-type lung cancers.
  • Clinicians should be aware of the increased likelihood of false-negative PET scans for smaller lesions and specific tumor subtypes.
  • These findings highlight the need for careful interpretation of PET scans in conjunction with other diagnostic modalities for lung cancer.