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Monosomy 3 and isochromosome 8q in a uveal melanoma
D E Horsman1, H Sroka, J Rootman
1Department of Pathology, Vancouver General Hospital, B. C., Canada.
Cancer Genetics and Cytogenetics
|April 1, 1990
Abstract:
Chromosome analysis of a locally invasive uveal melanoma revealed monosomy 3 and i(8q). Sublines with multiple copies of the i(8q) were also present. Loss of heterozygosity for genes on chromosome 3 and duplication of genes on 8q may play an important role in progression of uveal melanoma.